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B-cell acute lymphoblastic leukemia - historical

1,205 bytes added, 13:33, 10 December 2018
m
Consolidation after upfront therapy
===References===
# Evans WE, Crom WR, Abromowitch M, Dodge R, Look AT, Bowman WP, George SL, Pui CH. Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia: identification of a relation between concentration and effect. N Engl J Med. 1986 Feb 20;314(8):471-7. [https://www.nejm.org/doi/full/10.1056/NEJM198602203140803 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/3456079 PubMed]
 
=Maintenance after upfront therapy=
==Methotrexate monotherapy {{#subobject:478e97|Regimen=1}}==
{| class="wikitable" style="float:right; margin-left: 5px;"
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|[[#top|back to top]]
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===Regimen {{#subobject:028121|Variant=1}}===
{| class="wikitable" style="width: 100%; text-align:center;"
!style="width: 25%"|Study
!style="width: 25%"|[[Levels_of_Evidence#Evidence|Evidence]]
!style="width: 25%"|Comparator
!style="width: 25%"|[[Levels_of_Evidence#Efficacy|Efficacy]]
|-
|[https://jamanetwork.com/journals/jama/article-abstract/656675 Selawry & Holland 1965]
|style="background-color:#1a9851"|Randomized (E)
|PO MTX
| style="background-color:#1a9850" |Superior RFS
|-
|}
====Preceding treatment====
*Vincristine & Prednisone induction
====Chemotherapy====
*[[Methotrexate (MTX)]] IV
 
===References===
# Selawry OS, Holland JF; Acute leukemia group B. New treatment schedule with improved survival in childhood leukemia: intermittent parenteral vs daily oral administration of methotrexate for maintenance of induced remission. JAMA. 1965 Oct 4;194(1):75-81. [https://jamanetwork.com/journals/jama/article-abstract/656675 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/5896942 PubMed]
=Relapsed or refractory=
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