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B-cell acute lymphoblastic leukemia - historical

1,205 bytes added, 13:33, 10 December 2018
Consolidation after upfront therapy
# Evans WE, Crom WR, Abromowitch M, Dodge R, Look AT, Bowman WP, George SL, Pui CH. Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia: identification of a relation between concentration and effect. N Engl J Med. 1986 Feb 20;314(8):471-7. [ link to original article] [ PubMed]
=Maintenance after upfront therapy=
==Methotrexate monotherapy {{#subobject:478e97|Regimen=1}}==
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|[[#top|back to top]]
===Regimen {{#subobject:028121|Variant=1}}===
{| class="wikitable" style="width: 100%; text-align:center;"
!style="width: 25%"|Study
!style="width: 25%"|[[Levels_of_Evidence#Evidence|Evidence]]
!style="width: 25%"|Comparator
!style="width: 25%"|[[Levels_of_Evidence#Efficacy|Efficacy]]
|[ Selawry & Holland 1965]
|style="background-color:#1a9851"|Randomized (E)
| style="background-color:#1a9850" |Superior RFS
====Preceding treatment====
*Vincristine & Prednisone induction
*[[Methotrexate (MTX)]] IV
# Selawry OS, Holland JF; Acute leukemia group B. New treatment schedule with improved survival in childhood leukemia: intermittent parenteral vs daily oral administration of methotrexate for maintenance of induced remission. JAMA. 1965 Oct 4;194(1):75-81. [ link to original article] [ PubMed]
=Relapsed or refractory=
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