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B-cell acute lymphoblastic leukemia - historical

1,124 bytes added, 23:08, 1 December 2018
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Mercaptopurine & Methotrexate {{#subobject:6366a6|Regimen=1}}
===References===
# Frei E 3rd, Holland JF, Schneiderman MA, Pinkel D, Selkirk G, Freireich EJ, Silver RT, Gold GL, Regelson W. A comparative study of two regimens of combination chemotherapy in acute leukemia. Blood. 1958 Dec;13(12):1126-48. [http://www.bloodjournal.org/content/13/12/1126.long link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/13596417 PubMed]
 
==Mercaptopurine & Prednisone {{#subobject:f609f5|Regimen=1}}==
{| class="wikitable" style="float:right; margin-left: 5px;"
|-
|[[#top|back to top]]
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===Regimen {{#subobject:c637f6|Variant=1}}===
{| class="wikitable" style="width: 100%; text-align:center;"
!style="width: 25%"|Study
!style="width: 25%"|[[Levels_of_Evidence#Evidence|Evidence]]
!style="width: 25%"|Comparator
!style="width: 25%"|[[Levels_of_Evidence#Efficacy|Efficacy]]
|-
|[https://www.nejm.org/doi/full/10.1056/NEJM196609012750901 Fernbach et al. 1966]
|style="background-color:#1a9851"|Randomized (C)
|Cyclophosphamide & Prednisone
|style="background-color:#ffffbf"|Seems not superior
|-
|}
====Chemotherapy====
*[[Mercaptopurine (Purinethol)]]
*[[Prednisone (Sterapred)]]
 
===References===
# Fernbach DJ, Griffith KM, Haggard ME, Holcomb TM, Sutow WW, Vietti TJ, Windmiller J. Chemotherapy of acute leukemia in childhood. Comparison of cyclophosphamide and mercaptopurine. N Engl J Med. 1966 Sep 1;275(9):451-6. [https://www.nejm.org/doi/full/10.1056/NEJM196609012750901 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/5917939 PubMed]
==Prednisolone monotherapy {{#subobject:5d40b1|Regimen=1}}==
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