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B-cell acute lymphoblastic leukemia - historical

1,707 bytes added, 22:08, 1 December 2018
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Mercaptopurine & Methotrexate {{#subobject:6366a6|Regimen=1}}
===References===
# Frei E 3rd, Holland JF, Schneiderman MA, Pinkel D, Selkirk G, Freireich EJ, Silver RT, Gold GL, Regelson W. A comparative study of two regimens of combination chemotherapy in acute leukemia. Blood. 1958 Dec;13(12):1126-48. [http://www.bloodjournal.org/content/13/12/1126.long link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/13596417 PubMed]
 
==Prednisolone monotherapy {{#subobject:5d40b1|Regimen=1}}==
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===Regimen {{#subobject:b66a94|Variant=1}}===
{| class="wikitable" style="width: 100%; text-align:center;"
!style="width: 50%"|Study
!style="width: 50%"|[[Levels_of_Evidence#Evidence|Evidence]]
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|[https://www.nejm.org/doi/full/10.1056/NEJM196206282662603 Shanbrom & Miller 1962]
| style="background-color:#91cf61" |Non-randomized
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====Chemotherapy====
*[[Prednisolone (Millipred)]]
===References===
# Shanbrom E, Miller S. Critical evaluation of massive steroid therapy of acute leukemia. N Engl J Med. 1962 Jun 28;266:1354-8. [https://www.nejm.org/doi/full/10.1056/NEJM196206282662603 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/13911203 PubMed]
 
==Prednisone monotherapy {{#subobject:5eeb7e|Regimen=1}}==
{| class="wikitable" style="float:right; margin-left: 5px;"
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===Regimen {{#subobject:07e67b|Variant=1}}===
{| class="wikitable" style="width: 100%; text-align:center;"
!style="width: 50%"|Study
!style="width: 50%"|[[Levels_of_Evidence#Evidence|Evidence]]
|-
|[https://www.nejm.org/doi/full/10.1056/NEJM195807312590502 Granville et al. 1958]
| style="background-color:#91cf61" |Non-randomized
|-
|}
====Chemotherapy====
*[[Prednisone (Sterapred)]]
===References===
# Granville NB, Rubio F Jr, Unugur A, Schulman E, Dameshek W. Treatment of acute leukemia in adults with massive doses of prednisone and prednisolone. N Engl J Med. 1958 Jul 31;259(5):207-13. [https://www.nejm.org/doi/full/10.1056/NEJM195807312590502 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/13566450 PubMed]
=Consolidation after upfront therapy=
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