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B-cell acute lymphoblastic leukemia - historical

1,189 bytes added, 20:09, 1 December 2018
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Mercaptopurine & Methotrexate {{#subobject:7a01b3|Regimen=1}}
===References===
# Evans WE, Crom WR, Abromowitch M, Dodge R, Look AT, Bowman WP, George SL, Pui CH. Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia: identification of a relation between concentration and effect. N Engl J Med. 1986 Feb 20;314(8):471-7. [https://www.nejm.org/doi/full/10.1056/NEJM198602203140803 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/3456079 PubMed]
 
=Relapsed or refractory=
==TBI, then auto HSCT {{#subobject:1a2735|Regimen=1}}==
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TBI: '''<u>T</u>'''otal '''<u>B</u>'''ody '''<u>I</u>'''rradiation
===Regimen {{#subobject:635694|Variant=1}}===
{| class="wikitable" style="width: 100%; text-align:center;"
!style="width: 50%"|Study
!style="width: 50%"|[[Levels_of_Evidence#Evidence|Evidence]]
|-
|[https://www.nejm.org/doi/full/10.1056/NEJM195904022601401 McGovern et al. 1959]
| style="background-color:#ffffbe" |Pilot
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''This is of historic interest and likely the first reported use of autologous HSCT in the treatment of malignancy.''
====Radiotherapy====
*[[External_beam_radiotherapy|Total body irradiation]]
===References===
# McGovern JJ Jr, Russell PS, Atkins L, Webster EW, Duane M, Estes JW, Kelleher D. Treatment of terminal leukemic relapse by total-body irradiation and intravenous infusion of stored autologous bone marrow obtained during remission. N Engl J Med. 1959 Apr 2;260(14):675-83. [https://www.nejm.org/doi/full/10.1056/NEJM195904022601401 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/13644566 PubMed]
[[Category:B-cell acute lymphoblastic leukemia regimens]]
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