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Thioguanine (Tabloid)

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Also known as 6-TG, 6-thioguanine, or 2-Amino-6-Mercaptopurine.
 
==General information==
Class/mechanism: Purine (guanine) analog, antimetabolite that interferes with DNA synthesis. Thioguanine competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) and is converted to 6-thioguanylic acid (TGMP). TGMP interferes with several processes involving the synthesis of guanine nucleotides. It exerts pseudo-feedback inhibition of glutamine-5-phosphoribosylpyrophosphate amidotransferase, an early enzyme in the de novo pathway for purine ribonucleotide synthesis. TGMP is a competitive inhibitor of inosinic acid (IMP) dehydrogenase, interfering with the conversion of IMP to xanthylic acid (XMP). Thioguanylic acid is converted to thioguanosine diphosphate (TGDP) and thioguanosine triphosphate (TGTP), and they are eventually incorporated into RNA and DNA, which may cause additional cytotoxicity. Thioguanine is structurally and functionally similar to [[Mercaptopurine (Purinethol)]].<ref name="insert">[http://us.gsk.com/products/assets/us_tabloid.pdf Thioguanine (Tabloid) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/thioguanine.pdf Thioguanine (Tabloid) package insert (locally hosted backup)]</ref>
==Diseases for which it is used==
*[[Acute lymphocytic myeloid leukemia]]
*[[Acute promyelocytic leukemia]]
*[[B-cell acute lymphoblastic leukemia]]
==Patient drug information==
==History of changes in FDA indication==
* 1/18/1966: Initial FDA approval
 
==Also known as==
*'''Generic names:''' 6-TG, 6-thioguanine, 2-Amino-6-Mercaptopurine
*'''Brand name:''' Tabloid
==References==
[[Category:Drug index]]
[[Category:Chemotherapy]]
[[Category:Oral medications]]
[[Category:Purine analogues]]
[[Category:Acute myeloid leukemia medications]]
[[Category:Acute promyelocytic leukemia medications]]
[[Category:B-cell acute lymphoblastic leukemia medications]]
[[Category:Acute promyelocytic leukemia medications]]
[[Category:Drugs FDA approved in 1966]]
[[Category:WHO Essential Cancer Medicine]]
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