Retinoblastoma

Section editor
	Elaine Fan, MD KU School of Medicine Wichita, KS, USA LinkedIn

Last updated on 2024-11-22: 1 regimens on this page 2 variants on this page

Adjuvant therapy

CEV (Carboplatin/Etoposide)

CEV: Carboplatin, Etoposide, Vincristine

Regimen variant #1, 3 cycles

Study	Dates of enrollment	Evidence	Comparator	Comparative Efficacy
Ye et al. 2024	2013-08 to 2024-03	Phase 3 (E-de-esc)	CEV x 6	Non-inferior DFS (primary endpoint) DFS60: 90.4% vs 89.2%

Note: The etoposide instructions are confusing on CT.gov; this will eventually be updated after dosing details in the manuscript have been reviewed.

Preceding treatment

• Unilateral enucleation

Chemotherapy

• Carboplatin (Paraplatin) by the following age-specific criteria:
  • Younger than 3 years old: 18.6 mg/kg IV once on day 1
  • 3 years old or older: 560 mg/m² IV once on day 1
• Etoposide (Vepesid) by the following age-specific criteria:
  • Younger than 3 years old: 5 mg/kg IV once per day on days 1 & 2
  • 3 years old or older: 150 mg/m² IV once per day on days 1 & 2
• Vincristine (Oncovin) by the following age-specific criteria:
  • Younger than 3 years old: 0.05 mg/kg IV once on day 1
  • 3 years old or older: 1.5 mg/m² IV once on day 1

21-day cycle for 3 cycles

Regimen variant #2, 6 cycles

Study	Dates of enrollment	Evidence	Comparator	Comparative Efficacy
Ye et al. 2024	2013-08 to 2024-03	Phase 3 (C)	CEV x 3	Non-inferior DFS (primary endpoint) DFS60: 89.2% vs 90.4%

Note: The etoposide instructions are confusing on CT.gov; this will eventually be updated after dosing details in the manuscript have been reviewed.

Preceding treatment

• Unilateral enucleation

Chemotherapy

• Carboplatin (Paraplatin) by the following age-specific criteria:
  • Younger than 3 years old: 18.6 mg/kg IV once on day 1
  • 3 years old or older: 560 mg/m² IV once on day 1
• Etoposide (Vepesid) by the following age-specific criteria:
  • Younger than 3 years old: 5 mg/kg IV once per day on days 1 & 2
  • 3 years old or older: 150 mg/m² IV once per day on days 1 & 2
• Vincristine (Oncovin) by the following age-specific criteria:
  • Younger than 3 years old: 0.05 mg/kg IV once on day 1
  • 3 years old or older: 1.5 mg/m² IV once on day 1

21-day cycle for 6 cycles

References

1. Ye H, Xue K, Zhang P, Chen R, Zhai X, Ling L, Xiao W, Tang L, Wang H, Mao Y, Ai S, Bi Y, Liu Q, Zou Y, Qian J, Yang H. Three vs 6 Cycles of Chemotherapy for High-Risk Retinoblastoma: A Randomized Clinical Trial. JAMA. 2024 Nov 19;332(19):1634-1641. link to original article link to PMC article dosing details on CT.gov have been reviewed by our editors PubMed NCT01906814