Obecabtagene autoleucel (Aucatzyl)
Mechanism of action
From the NCI Drug Dictionary: A preparation of autologous T lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a second-generation chimeric antigen receptor (CAR), CAT-41BBz CAR, targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, obecabtagene autoleucel target and bind to CD19-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. The CAT-41BBz CAR has a faster off-rate compared with FMC63-41BBz CAR. This may minimize cytokine release and reduce toxicities, and enhance persistence of the CAR T cells.
History of changes in FDA indication
- 2024-11-08: Approved for adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). (Based on FELIX)
Also known as
- Code name: AUTO-1
- Generic name: obe-cel
- Brand name: Aucatzyl