Guidelines

Clinical practice guidelines (CPGs) are a cornerstone of hematology/oncology practice, given the increasing complexity of the fields. On HemOnc.org, we primarily organize guidelines by the disease(s) on which they focus. For example, the HER2+ breast cancer page contains guidelines pertinent to HER2+ breast cancer, whereas the more generic breast cancer guidelines are to be found on the breast cancer page.

Topical guidelines are to be found on the relevant page; for example, immune effector cell toxicity management guidelines are found on the IEC toxicity page.

For links directly to professional society guidelines, please visit this page.

Major Guidelines Organizations

American Society of Clinical Oncology (ASCO)

• All ASCO guidelines are published in the Journal of Clinical Oncology. Companion articles are often published in JCO Oncology Practice.
• Dedicated ASCO guidelines landing page.
  • HemOnc.org ASCO guideline page

American Society of Hematology (ASH)

• Dedicated ASH guidelines landing page.

American Society for Transplant and Cellular Therapy (ASTCT)

• Dedicated ASTCT guidelines landing page.

European Society of Medical Oncology (ESMO)

• Many, but not all, ESMO guidelines are published in Annals of Oncology or ESMO Open. Some ESMO guidelines are published elsewhere.
• Dedicated ESMO guidelines landing page.
  • HemOnc.org ESMO guideline page

National Comprehensive Cancer Network (NCCN)

• Some NCCN guidelines are published in JNCCN.
• Dedicated NCCN guidelines landing page
  • HemOnc.org NCCN guideline page

Other Guidelines

A substantial number of professional organizations provide guidelines; please visit the professional organizations page to learn more. Over time, we will add links to the dedicated guidelines pages for these organizations.

• Childhood Cancer Predisposition Screening Recommendations
  • American Association for Cancer Research (AACR)
    • Li-Fraumeni Syndrome: 2017: Kratz et al. Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome Pubmed
    • Leukemia-Predisposition: 2017: Porter et al. Recommendations for Surveillance for Children with Leukemia-Predisposing Conditions Pubmed
    • DNA Repair Disorders: 2017: Walsh et al. Recommendations for Childhood Cancer Screening and Surveillance in DNA Repair Disorders Pubmed
    • Inherited Mismatch Repair Deficiency: 2017: Tabori et al. Clinical Management and Tumor Surveillance Recommendations of Inherited Mismatch Repair Deficiency in Childhood Pubmed
    • Pediatric NF-1: 2017: Evans et al. Cancer and Central Nervous System Tumor Surveillance in Pediatric Neurofibromatosis 1 Pubmed
    • Pediatric NF-2: 2017: Gareth & Evans et al. Cancer and Central Nervous System Tumor Surveillance in Pediatric Neurofibromatosis 2 and Related Disorders Pubmed
    • Gorlin Syndrome & Rhabdoid Tumor Predisposition: 2017: Foulkes et al. Cancer Surveillance in Gorlin Syndrome and Rhabdoid Tumor Predisposition Syndrome Pubmed
    • VHL & Hereditary Pheochromocytoma/Paraganglioma Syndromes: 2017: Rednam et al. Von Hippel–Lindau and Hereditary Pheochromocytoma/Paraganglioma Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood Pubmed
    • PTEN, DICER1, FH, & Their Associated Tumor Susceptibility Syndromes: 2017: Schultz et al. PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood Pubmed
    • RASopathies: 2017: Villani et al. Recommendations for Cancer Surveillance in Individuals with RASopathies and Other Rare Genetic Conditions with Increased Cancer Risk Pubmed
    • Retinoblastoma & Neuroblastoma: 2017: Kamihara et al. Retinoblastoma and Neuroblastoma Predisposition and Surveillance Pubmed
    • Inherited GI Cancer Syndromes: 2017: Achatz et al. Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood Pubmed
    • Overgrowth Syndromes: 2017: Kalish et al. Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma Pubmed
    • MEN Syndromes: 2017: Wasserman et al. Multiple Endocrine Neoplasia and Hyperparathyroid-Jaw Tumor Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood Pubmed
  • SIOPE and CanGene-CanVar
    • DICER1: 2021: Bakhuizen et al. Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group Pubmed

Quality of evidence and strength of recommendations

GRADE (Grading of Recommendations Assessment, Development, and Evaluation)

1. Guyatt et al. 2011 GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables PubMed
2. Balshem et al. 2011 GRADE guidelines: 3. Rating the quality of evidence PubMed