Gemcitabine & Oxaliplatin in all diseases

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Biliary tract cancer (cholangiocarcinoma/gallbladder)

Source: Gemcitabine & Oxaliplatin for biliary tract cancer

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GEMOX-3: GEMcitabine & OXaliplatin, 3 visits per month

Regimen variant #1, 1000/85, bi-weekly

Study Evidence Efficacy
Halim et al. 2011 Phase II ORR: 27.5%


14-day cycles

Regimen variant #2, 1000/100, bi-weekly

Study Evidence Comparator Comparative Efficacy
Lee et al. 2011 (SMC 2008-12-024) Phase III (C) GEMOX & Erlotinib Might have inferior PFS


14-day cycles

Regimen variant #3, 1000/100 ("GEMOX-3")

Study Evidence Efficacy
Harder et al. 2006 Phase II ORR: 26% (95% CI 14–44)


28-day cycles


  1. Harder J, Riecken B, Kummer O, Lohrmann C, Otto F, Usadel H, Geissler M, Opitz O, Henss H. Outpatient chemotherapy with gemcitabine and oxaliplatin in patients with biliary tract cancer. Br J Cancer. 2006 Oct 9;95(7):848-52. link to PMC article contains verified protocol PubMed
  2. Halim A, Ebrahim MA, Saleh Y. A phase II study of outpatient biweekly gemcitabine-oxaliplatin in advanced biliary tract carcinomas. Jpn J Clin Oncol. 2011 Feb;41(2):217-24. link to original article contains verified protocol PubMed
  3. SMC 2008-12-024: Lee J, Park SH, Chang HM, Kim JS, Choi HJ, Lee MA, Jang JS, Jeung HC, Kang JH, Lee HW, Shin DB, Kang HJ, Sun JM, Park JO, Park YS, Kang WK, Lim HY. Gemcitabine and oxaliplatin with or without erlotinib in advanced biliary-tract cancer: a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2012 Feb;13(2):181-8. Epub 2011 Dec 20. link to original article contains protocol PubMed