Fluorouracil & cisplatin in all diseases

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Anal cancer

Source: Fluorouracil & cisplatin for anal cancer

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Regimen

Variant #1, 100/5000 every 4 weeks

Study Evidence
Faivre et al. 1999 Pilot, <20 patients reported

Chemotherapy

28-day cycles

Variant #2, 60/4000 every 3 weeks

Study Evidence Comparator Comparative Efficacy
Sclafani et al. 2017 Phase II Carboplatin & Paclitaxel Not reported

Chemotherapy

21-day cycles

References

  1. Faivre C, Rougier P, Ducreux M, Mitry E, Lusinchi A, Lasser P, Elias D, Eschwege F. [5-fluorouracile and cisplatinum combination chemotherapy for metastatic squamous-cell anal cancer]. Bull Cancer. 1999 Oct;86(10):861-5. link to original article & English summary contains protocol PubMed
  2. Sclafani F et al. [InterAACT: An international multicenter open label randomized phase II advanced anal cancer trial comparing cisplatin (CDDP) plus 5-fluorouracil (5-FU) versus carboplatin (CBDCA) plus weekly paclitaxel (PTX) in patients with inoperable locally recurrent (ILR) or metastatic disease]. Journal of Clinical Oncology. 2015 33:3_suppl, TPS792-TPS792. link to original article contains protocol clinicaltrials.gov