Finotonlimab (SCT-I10A)

Mechanism of action

From NCI Drug Dictionary: A recombinant, humanized monoclonal antibody directed against the negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-1 monoclonal antibody SCT-I10A targets, binds to, and inhibits PD-1 and its downstream signaling pathways. This may restore immune functions through the activation of T cells and T-cell-mediated immune responses against tumor cells.

Preliminary data

Head and neck cancer

1. SCT-I10A-B301: Shi Y, Guo W, Wang W, Wu Y, Fang M, Huang X, Han P, Zhang Q, Dong P, Zhou X, Peng H, Hu C, Chen X, Zhang S, Chang Z, Li X, Ding Y, Qu S, Jing S, Zhang S, Gui L, Sun Y, Wang L, Liu Y, Wu H, Li G, Fu Z, Shi J, Jiang H, Bai Y, Cui J, Zheng Y, Cui W, Jia X, Zhai L, Cai Q, Xiong D, Wu Y, Cao J, Wu R, Hu G, Peng L, Xie L, Gai W, Wang Y, Su Y. Finotonlimab with chemotherapy in recurrent or metastatic head and neck cancer: a randomized phase 3 trial. Nat Med. 2024 Sep;30(9):2568-2575. Epub 2024 Jun 28. link to original article PubMed NCT04146402

Also known as

• Code name: SCT-I10A