Dalpiciclib (SHR6390)

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Mechanism of action

From NCI Drug Dictionary: A cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Upon administration, dalpiciclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6). This inhibits retinoblastoma (Rb) protein phosphorylation early in the G1 phase, which prevents CDK-mediated G1-S phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation.

Preliminary data

Breast cancer, ER-positive

  • DAWNA-1: NCT03927456

Also known as

  • Code name: SHR6390

References