Cyclosporine non-modified (Sandimmune)

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General information

Class/mechanism: Cyclic polypeptide immunosuppressive agent that reversibly and preferentially inhibits T-lymphocytes, especially the T-helper cell. Exact mechanism unknown. Suppresses humoral immunity and cell-mediated immune reactions, including graft vs. host disease, allograft rejection, delayed hypersensitivity, experimental allergic encephalomyelitis, and Freund’s adjuvant arthritis.[1][2]
Route: IV, PO
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

Also known as

  • Generic names: ciclosporin, CsA, CyA, cyclosporin, cyclosporin A
  • Brand name: Sandimmune

References

  1. 1.0 1.1 1.2 Cyclosporine non-modified (Sandimmune) package insert
  2. Cyclosporine non-modified (Sandimmune) package insert (locally hosted backup)
  3. Cyclosporine non-modified (Sandimmune) patient drug information (UpToDate)