Cisplatin & Gemcitabine in all diseases

Bladder cancer, neoadjuvant

Source: Cisplatin & Gemcitabine for bladder cancer, neoadjuvant

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GC: Gemcitabine, Cisplatin

Variant #1, single-dose cisplatin

Study	Evidence
Dash et al. 2008	Retrospective

Chemotherapy

• Cisplatin (Platinol) 70 mg/m² IV once on day 1
• Gemcitabine (Gemzar) 1000 mg/m² IV once per day on days 1 & 8

21-day cycle for 4 cycles

Subsequent treatment

• Surgery

Variant #2, split-dose cisplatin

Study	Evidence
Dash et al. 2008	Retrospective

Chemotherapy

• Cisplatin (Platinol) 35 mg/m² IV once per day on days 1 & 8
• Gemcitabine (Gemzar) 1000 mg/m² IV once per day on days 1 & 8

21-day cycle for 4 cycles

Subsequent treatment

• Surgery

References

1. Retrospective: Dash A, Pettus JA 4th, Herr HW, Bochner BH, Dalbagni G, Donat SM, Russo P, Boyle MG, Milowsky MI, Bajorin DF. A role for neoadjuvant gemcitabine plus cisplatin in muscle-invasive urothelial carcinoma of the bladder: a retrospective experience. Cancer. 2008 Nov 1;113(9):2471-7. link to PMC article contains verified protocol PubMed