Class/mechanism: Human monoclonal antibody that neutralizes Dickkopf-1 (DKK-1). DKK-1 is an antagonist of the Wnt pathway, which regulates differentiation of mesenchymal stem cells (MSC) into osteoblasts and promotes survival of active osteoblasts. Myeloma cells have been observed to overexpress DKK-1, blocking osteoblast differentiation, and promoting bone resorption. By neutralizing DKK-1, it is hypothesized that BHQ880 will promote bone formation and inhibit tumor-associated osteolytic processes.
Extravasation: no information
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Patient drug information
No information available.