Anaplastic large cell lymphoma, pediatric - historical

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Section editor
David Noyd, MD, MPH
University of Washington
Seattle, WA, USA

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The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. Is there a regimen missing from this list? See the main pediatric anaplastic large cell lymphoma page for current regimens.

Last updated on 2024-10-04:
2 regimens on this page
2 variants on this page


Historical

EICNHL ALCL99 protocol

Study Dates of enrollment Evidence Comparator Comparative Efficacy Comparative Toxicity
Brugières et al. 2009 (EICNHL ALCL99) 1999-2005 Randomized (E-switch-ic) EICHNL ALCL99; alternate MTX dosing Inconclusive whether non-inferior EFS (primary endpoint) Less toxic

Note: the intrathecal component is only described as "triple therapy" in the manuscript.

Pre-phase

Chemotherapy

Glucocorticoid therapy

CNS therapy, prophylaxis

5-day course


Induction

Chemotherapy

Glucocorticoid therapy

21-day cycle for 6 cycles

References

  1. EICNHL ALCL99: Brugières L, Le Deley MC, Rosolen A, Williams D, Horibe K, Wrobel G, Mann G, Zsiros J, Uyttebroeck A, Marky I, Lamant L, Reiter A. Impact of the methotrexate administration dose on the need for intrathecal treatment in children and adolescents with anaplastic large-cell lymphoma: results of a randomized trial of the EICNHL Group. J Clin Oncol. 2009 Feb 20;27(6):897-903. Epub 2009 Jan 12. link to original article dosing details in manuscript have been reviewed by our editors PubMed NCT00006455


APO

APO: Adriamycin (Doxorubicin), Prednisone, Oncovin (Vincristine)
HOP: Hydroxydaunorubicin (Doxorubicin), Oncovin (Vincristine), Prednisone

Regimen

Study Dates of enrollment Evidence
Alexander et al. 2014 (COG ANHL0131) 2004-2008 Non-randomized part of phase 3 RCT

Chemotherapy

Glucocorticoid therapy

CNS therapy, prophylaxis

6-week course

Subsequent treatment

References

  1. COG ANHL0131: Alexander S, Kraveka JM, Weitzman S, Lowe E, Smith L, Lynch JC, Chang M, Kinney MC, Perkins SL, Laver J, Gross TG, Weinstein H. Advanced stage anaplastic large cell lymphoma in children and adolescents: results of ANHL0131, a randomized phase III trial of APO versus a modified regimen with vinblastine: a report from the children's oncology group. Pediatr Blood Cancer. 2014 Dec;61(12):2236-42. Epub 2014 Aug 23. link to original article link to PMC article dosing details in manuscript have been reviewed by our editors PubMed NCT00059839