Class/mechanism: Topoisomerase II inhibitor. Teniposide inhibits type II topoisomerase, which results in single and double-stranded DNA breaks and DNA-protein crosslinks. It is cell-cycle specific, acting in late S or early G2, preventing cells from entering mitosis. It is dissolved in Cremophor EL (polyoxyethylated castor oil), which may cause hypersensitivity infusion reactions.
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Diseases for which it is used
Diseases for which it was used
Patient drug information
Also known as
- Code name: VM-26
- Brand name: Vumon
History of changes in FDA indication
- 7/14/1992: Initial FDA approval