Class/mechanism: mTOR (mammalian target of rapamycin) inhibitor. mTOR inhibition by temsirolimus interferes with the ability of mTOR to phosphorylate downstream targets in the PI3 kinase/AKT pathway, such as p70S6k and the S6 ribosomal protein. Temsirolimus has also been observed to reduce levels of VEGF (vascular endothelial growth factor) and hypoxia-inducible factors HIF-1 and HIF-2 alpha.
Extravasation: no information
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Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 5/30/2007: Initial FDA approval for the treatment of advanced renal cell carcinoma.
Also known as
- Code name: CCI-779
- Brand name: Torisel