Semustine (MeCCNU)

General information

Class/mechanism: Nitrosourea, alkylates DNA and RNA and may inhibit certain key enzymatic reactions by carbamoylation of amino acids in proteins. Very similar to lomustine, with a methyl group added.
Route: PO
Extravasation: n/a

Diseases for which it was used

• Colorectal cancer
• Colon cancer

Also known as

• Generic names: MeCCNU, methyl-CCNU, methyl-lomustine
• Brand names: Semustina