Class/mechanism: Purine (adenosine) analog, inhibitor of adenosine deaminase (ADA), causes elevated intracellular levels of dATP, and inhibits ribonucleotide reductase, which interferes with DNA synthesis. Pentostatin can also inhibit RNA synthesis and has been observed to cause DNA damage. ADA enzymatic activity is greater in T-cell malignancies compared to B-cell malignancies. Exact mechanism of action in hairy cell leukemia is not fully understood.
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Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 10/11/1991: Initial FDA approval for treatment for adult patients with alpha-interferon-refractory hairy cell leukemia
Also known as
- Generic names: 2'-deoxycoformycin, dCF
- Brand name: Nipent