Class/mechanism: Depletes plasma asparagine, selectively killing leukemic cells which are unable to synthesize asparagine due to a lack of asparagine synthetase. The Oncaspar formulation involves L-asparaginase (L-asparagine amidohydrolase) being covalently conjugated to monomethoxypolyethylene glycol (mPEG), increasing its half-life and reducing the risk of hypersensitivity reactions in patients who have history of hypersensitivity to Asparaginase (Elspar).
Route: IV, IM
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Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 2/1/1994: Initial FDA approval
- 7/24/2006: FDA approved for the first-line treatment of patients with acute lymphoblastic leukemia.
Also known as
- Generic names: PEG-L-asparaginase, peg-asparginase, pegasparaginase
- Brand name: Oncaspar