Class/mechanism: Microtubule inhibitor; semi-synthetic analog of epothilone B. Ixabepilone binds to beta tubulin on microtubules, suppresses the dynamic instability of alpha beta II and alpha beta III, and disrupts normal microtubule dynamics. This results in arrest in the mitotic phase of the cell cycle and cell death.
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Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 10/16/2007: Initial FDA approval:
- In combination with capecitabine is indicated for the treatment of metastatic or locally advanced breast cancer in patients after failure of an anthracycline and a taxane
- As monotherapy is indicated for the treatment of metastatic or locally advanced breast cancer in patients after failure of an anthracycline, a taxane, and capecitabine
Also known as
- Code name: BMS-247550
- Generic names: azaepothilone B, epothilone B lactam
- Brand name: Ixempra