Class/mechanism: Purine analog, antimetabolite; fludarabine is converted to the active compound, 2-fluoro-ara-ATP, which inhibits DNA synthesis by inhibiting DNA polymerase alpha, ribonucleotide reductase, and DNA primase. Relatively resistant to deamination by adenosine deaminase. The mechanism of action is not completely characterized and may be multi-faceted.
Route: IV, PO Note: Oral fludarabine is no longer available in the US, at this time.
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Diseases for which it is used
Diseases for which it was used
Patient drug information
History of changes in FDA indication
Also known as
- Generic names: FAMP, fludarabine phosphate
- Brand names: Beneflur, Fludabine, Fludara, Lymfuda, Oforta