Class/mechanism: Anthracycline, binds and intercalates between DNA base pairs. Inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, resulting in single and double strand DNA breaks. May also inhibit polymerase activity and trigger free radical damage to DNA.
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.
Diseases for which it is used
- Per Feijen et al. 2015 , daunorubicin appears to be significantly less cardiotoxic than doxorubicin in survivors of childhood cancer.
Patient drug information
History of changes in FDA indication
- 12/19/1979: Initial FDA approval
Also known as
- Generic name: daunomycin
- Brand names: Cerubidin, Cerubidine, D-Blastin, Daunoblastin, Daunoblastina, Daunocin, Daunomicina, Daunorubicine, Daurocina, Maxidauno, Ondena, Rubidomycin, Rubilem, Rubomycin, Runabicon
- Daunorubicin (Cerubidine) package insert
- Daunorubicin (Cerubidine) package insert (locally hosted backup)
- Feijen EA, Leisenring WM, Stratton KL, Ness KK, van der Pal HJ, Caron HN, Armstrong GT, Green DM, Hudson MM, Oeffinger KC, Robison LL, Stovall M, Kremer LC, Chow EJ. Equivalence Ratio for Daunorubicin to Doxorubicin in Relation to Late Heart Failure in Survivors of Childhood Cancer. J Clin Oncol. 2015 Nov 10;33(32):3774-80. Epub 2015 Aug 24.link to original article PubMed
- Daunorubicin (Cerubidine) patient drug information (Chemocare)
- Daunorubicin (Cerubidine) patient drug information (UpToDate)