Belotecan (Camptobell)
General information
Class/mechanism from the NCI Drug Dictionary: The hydrochloride salt of the semi-synthetic camptothecin analog belotecan with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis.
Route: IV
Extravasation: irritant
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Diseases for which it is used
Also known as
- Code name: CKD-602
- Generic name: belotecan hydrochloride
- Brand name: Camptobell