Acetaminophen (Tylenol)

General information

Class/mechanism: Antipyretic / Not completely understood. The main mechanism proposed is the inhibition of cyclooxygenase (COX), and recent findings suggest that it is highly selective for COX-2.
Routes: PO, PR
Extravasation: N/A

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

No known antineoplastic properties. Used as a supportive medications especially prior to blood product and biologic product (e.g. monoclonal antibody) infusions.

Also known as

• Generic names: APAP, paracetamol, paracetamole
• Brand names: Calpol, Panadol, Tylenol