Difference between revisions of "Leucovorin (Folinic acid)"

Revision as of 15:28, 3 December 2017

General information

Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of Fluorouracil (5-FU) by inhibiting thymidylate synthase.^[1]^[2]
Route: PO, IM, IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Note: these are diseases where folinic acid is used as an adjuvant to Fluorouracil (5-FU), as opposed to an antidote as it is used in conjunction with Methotrexate (MTX)

Patient drug information

History of changes in FDA indication

6/20/1952: Initial FDA approval

Also known as

Synonyms
Abic Leucovorin	AC.folinico GI	AI JIE Kang	Antrex	Asovorin	Biovorin	BO Sheng	Buateron
Calcifolin	Calcio Folinato	Calciumfolin	Calciumfolinat	Calciumfolinat-GRY	Calciumfolinat Ebewe	Calciumfolinat Hexal	Calciumfolinat Mayne
Calcium Folinato	Calcium Folint	Calcium Leucovorin	Calcium Leucovorn	Calcivoran	Calc Leucovorn	Calfolex	Calfolin
Calinat	Cehafolin	Citofolin	Citrovorum Factor	Claro	Cromatonbic Folinico	Dalisol	Degalin
Divifolin	Durofolin	Ecofol	Elvefocal	Emovis	Erbanfol	Estroquin	Fastovorin
Fauldleuco	Fayining	Fedolen	Ferbon	Folaren	Folaxin	Foliben	Folic Acid Roche
Foli Cell	Folidan	Folidar	Foliment	Folinac	Folinate Calcium	Folinate DE Calcium Aguettant	Folinate DE Calcium Dakota Pharm
Folinato	Folinato Calcico	Folinato Calcico Ferrer	Folinato DE Calcio	Folinfabra	Folinoral	Folinoxan	Folinvit
Foliplus	Folmigor	FU LI Neng	Ifavor	Isovorin	Kalciumfolinat Perivita	Kalsiumfolinat	Kunyrin
Lederfolat	Lederfolin	Lederfoline	Lederle Leucovorin	Ledervorin	Legifol	Leucocalcin	Leuconolver,Leucovorin
Leucovorina	Leucovorina Calcica	Leucovorina Calcica Teva	Leucovorina Calcico	Leucovorina Delta Farma	Leucovorina Filaxis	Leucovorina Raffo	Leucovorina Richet
Leucovorina Servycal	Leucovorin CA	Leucovorin Calcium	Leucovorin Calcium Farmos	Leucovorin Dabur	Leucovorine	Leucovorine Calcium	Leucovorin Lens
Leucovorin Teva	Leukovorin	Lovorin	Medicofolin	Medifolin	Medsavorina	Neofolin	Nyrin
O Folin	Osfolate	Osfolato	Perfolate	Prefolic	Prevax	Recovorin	Reotan
Rescuvolin	Resfolin	Ribofolin	Rontafor	Sanifolin	SHI Ming	Sodium Folinate	Tecnovorin
Tong AO	Tonofolin	Veravorin	Vorina	Wellcovorin	Zyofolin	Zytofolin

References

[insert-1] 1.0 ^1.1 Folinic acid (Leucovorin) package insert

[2] Folinic acid (Leucovorin) package insert (locally hosted backup)

[3] Folinic acid (Leucovorin) patient drug information (Chemocare)

[4] Folinic acid (Leucovorin) patient drug information (UpToDate)

[1]

[2]

[3]

[4]

@@ Line 4: / Line 4: @@
 <br>Extravasation: no information
-For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>
+For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>
 ==Diseases for which it is used==