Difference between revisions of "Autoimmune cytopenia"

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# Willis F, Marsh JC, Bevan DH, Killick SB, Lucas G, Griffiths R, Ouwehand W, Hale G, Waldmann H, Gordon-Smith EC. The effect of treatment with Campath-1H in patients with autoimmune cytopenias. Br J Haematol. 2001 Sep;114(4):891-8.[http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2001.03039.x/full link to original article]  [https://www.ncbi.nlm.nih.gov/pubmed/11564082 PubMed]
 
# Willis F, Marsh JC, Bevan DH, Killick SB, Lucas G, Griffiths R, Ouwehand W, Hale G, Waldmann H, Gordon-Smith EC. The effect of treatment with Campath-1H in patients with autoimmune cytopenias. Br J Haematol. 2001 Sep;114(4):891-8.[http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2001.03039.x/full link to original article]  [https://www.ncbi.nlm.nih.gov/pubmed/11564082 PubMed]
  
==Sirolimus (Rapamune) {{#subobject:35516b|Regimen=1}}==
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==Sirolimus monotherapy {{#subobject:35516b|Regimen=1}}==
 
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====Immunosuppressant therapy====
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====Immunosuppressive therapy====
 
*[[Sirolimus (Rapamune)]] 2  to 2.5 mg/m2/day PO
 
*[[Sirolimus (Rapamune)]] 2  to 2.5 mg/m2/day PO
 
**See manuscript for recommended dose adjustments
 
**See manuscript for recommended dose adjustments

Revision as of 08:03, 9 October 2017

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Is there a regimen missing from this list? Would you like to share a different dosage/schedule or an additional reference for a regimen? Have you noticed an error? Do you have an idea that will help the site grow to better meet your needs and the needs of many others? You are invited to contribute to the site.

2 regimens on this page
2 variants on this page


This is an umbrella category that includes Felty's syndrome (autoimmune neutropenia), autoimmune thrombocytopenia (ITP), autoimmune hemolytic anemia (AIHA), and Evan's syndrome (AIHA & ITP). Please see the respective page(s) for disease-specific therapies. This page includes regimens that were used more broadly.

Guidelines

British Society for Haematology

Relapsed/refractory

Alemtuzumab monotherapy

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Regimen

Study Evidence
Willis et al. 2001 Phase II

To be completed

References

  1. Willis F, Marsh JC, Bevan DH, Killick SB, Lucas G, Griffiths R, Ouwehand W, Hale G, Waldmann H, Gordon-Smith EC. The effect of treatment with Campath-1H in patients with autoimmune cytopenias. Br J Haematol. 2001 Sep;114(4):891-8.link to original article PubMed

Sirolimus monotherapy

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Regimen

Study Evidence
Bride et al. 2015 Phase II

Immunosuppressive therapy

6-month course, extended for those with a favorable response

References

  1. Bride KL, Vincent T, Smith-Whitley K, Lambert MP, Bleesing JJ, Seif AE, Manno CS, Casper J, Grupp SA, Teachey DT. Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial. Blood. 2016 Jan 7;127(1):17-28. Epub 2015 Oct 26. link to original article link to PMC article contains protocol PubMed