Ondansetron (Zofran)

General information

Class/mechanism: Selective serotonin 5-HT3 receptor antagonist. Chemotherapy medications can cause nausea and vomiting by stimulating release of serotonin from the enterochromaffin cells of the small intestine, and serotonin triggers the vomiting reflex by binding to and activating 5-HT3 receptors. Ondansetron prevents nausea and vomiting by binding with high affinity to 5-HT3 receptors and blocking their activation by serotonin.
Route: PO, IV
Extravasation: no information available

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Patient drug information

• Patient counseling information can be found in the Ondansetron (Zofran) package insert
• Ondansetron (Zofran) patient drug information (UpToDate)

History of changes in FDA indication

• 1991-01-04: Initial FDA approval

Also known as

• Code name: SN-307
• Brand names:

Synonyms
Alencar	Amilene	Ansentron	Anset	Atossa	Bryterol	Cedantron	Ceramos
Danofran	Dantenk	Emeran	Emeset	Emetra	Emetron	Emigo	Emistat
Emivox	Espasevit	Finaber	Finoxi	Frazon	Glendan	Helmine	Injectrax
Insetron	Invomit	Izofran	Latran	Modifical	Narfoz	Nausedron	Nautah
Neomit	Nuset	O.N.D.	Odanex	Odanse	Ometic	Omstron	Onaset
Oncotor	Onda	Ondace	Ondan	Ondanles	Ondansetron-Z	Ondant	Ondaren
Ondasetron	Ondatie	Ondavell	Ondem	Ondemet	Onfran	Onilat	Onsat
Onseran	Onset	Onsetron	Onsett	Onsia	Ontrax	Onzod	Osetron
Ostasyn	Otobrol	Periset	Quimiofran	Seton	Setronax	Setronon	Sopran
Trorix	Vomceran	Vomiban	Vomigo	Vomikind	Vomiset	Vomitron	Vomiz
Vonau	Yatrox	Zantron	Zapron	Zemitron	Zofer	Zofran	Zofran ODT
Zofron	Zoltem	Zonax	Zondan	Zophren	Zudan	Zuplenz

References

• Italian Group for Antiemetic Research. Dexamethasone alone or in combination with ondansetron for the prevention of delayed nausea and vomiting induced by chemotherapy. N Engl J Med. 2000 May 25;342(21):1554-9. link to original article PubMed