Interferon alfa-2b (Intron-A)

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General information

Class/mechanism: Immune system activator; binds to cell surface receptors that modulate many downstream intracellular signal transduction pathways. Mechanism not fully understood.[1][2][3]
Route: SC, IM, IV, intralesional
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Diseases for which it was used

Patient drug information

History of changes in FDA indication

  • 1986-06-04: Initial FDA approval for treatment of patients 18 years of age or older with hairy cell leukemia. (Based on Golomb et al. 1988)
  • Uncertain date: Indicated as adjuvant to surgical treatment in patients 18 years of age or older with malignant melanoma who are free of disease but at high risk for systemic recurrence, within 56 days of surgery. (Based on ECOG E1684 & ECOG E1690)
  • Uncertain date: Indicated for the initial treatment of clinically aggressive follicular Non-Hodgkin’s Lymphoma in conjunction with anthracycline-containing combination chemotherapy in patients 18 years of age or older. Efficacy of INTRON A therapy in patients with low-grade, low tumor burden follicular Non-Hodgkin’s Lymphoma has not been demonstrated. (Based on GELA GELF-86)
  • Uncertain date: Indicated for the treatment of selected patients 18 years of age or older with AIDS-Related Kaposi's Sarcoma. (Based on Lane et al. 1988 & Volberding et al. 1987)

Also known as

Caution, may also contain names for interferon beta, interferon gamma, or interferon alfa-2a.

  • Brand names:
Synonyms
Advaferon Alfaferone Biogamma Canferon A Cytoferon Egiferon Feron Fiblaferon
Frone Finnferon-Alpha Heberon Alfa R Humoferon IFN Alpha Imufor Imukin INF
Inferax Infergen Inmutag Interfero Interferon Alfanative Interferon Human Interferon Leucocyticum Interferon Lymphoblastoid
Interferonum Leucocyticum Intron-A IntronA Multiferon Namalvin OIF Polyferon Realdiron
Roceron-A Sumiferon

References

  1. ↑ 1.0 1.1 1.2 Interferon alfa-2b (Intron-A) package insert
  2. ↑ Interferon alfa-2b (Intron-A) package insert (locally hosted backup)
  3. ↑ Intron-A manufacturer's website
  4. ↑ Interferon alfa-2b (Intron-A) patient drug information (Chemocare)
  5. ↑ Interferon alfa-2b (Intron-A) patient drug information (UpToDate)
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