Dacarbazine (DTIC)

General information

Class/mechanism: Alkylator, purine analog, inhibits DNA synthesis; exact mechanism unclear. Converted to the active alkylating metabolite MTIC.^[1]^[2]
Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is established (work in progress)

Diseases for which it is used

Patient drug information

History of changes in FDA indication

1975-05-27: Initial FDA approval
Uncertain date: indicated in the treatment of metastatic malignant melanoma. (No supporting studies are cited)
Uncertain date: Indicated for Hodgkin's disease as a second-line therapy when used in combination with other effective agents. (No supporting studies are cited)

History of changes in EMA indication

1978-02-01: EURD

History of changes in PMDA indication

2013-03-25: New additional indication and a new dosage for the treatment of pheochromocytoma.

Also known as

Generic names: dacarbazin, DTIC, imidazole carboxamide
Brand names: Bazipar, Cedcozine, Dacarba, Dacarex, Dacin, Dacmed, Darbazine, Dazine, Decarb, Oncodac, Zydac

References

[insert-1] 1.0 ^1.1 Dacarbazine (DTIC) package insert

[2] Dacarbazine (DTIC) package insert (locally hosted backup)

[3] Dacarbazine (DTIC) patient drug information (Chemocare)

[4] Dacarbazine (DTIC) patient drug information (UpToDate)

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