Antithymocyte globulin (ATG)

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Also known as anti-thymocyte globulin, antithymocyte globulin (equine), antithymocyte globulin (rabbit), Atgam, horse ATG, lymphocyte immune globulin, rabbit ATG, Thymoglobulin

General information

Class/mechanism: Contains antibodies against T-cell markers including CD2, CD3, CD4, CD8, CD11a, CD18, CD25, CD44, CD45, Beta-2 microglobulin, HLA Class I heavy chains, and HLA-DR. Exact mechanism not understood, but may involve removing T-cells from circulation and modifying T-cell activation, migration, proliferation, and cytotoxic effects.
Please choose from the products below to find specific drug/manufacturer information:

• Thymoglobulin (rabbit ATG)
• Atgam (horse ATG)

Route: IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

• Myelodysplastic syndrome
• Transplant conditioning regimens

Patient drug information

• Antithymocyte globulin (Thymoglobulin, rabbit ATG) patient drug information (UpToDate)
• Antithymocyte globulin (Atgam, horse ATG) patient drug information (UpToDate)