Diphenhydramine (Benadryl)

General information

Class/mechanism: first-generation antihistamine.
Route: PO/IV
Extravasation: unknown

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

No known antineoplastic properties. Used for prevention of reactions to blood products or biologics (e.g. monoclonal antibodies) as well as treatment of such reactions.

Also known as

• Brand name: Benadryl