Cyclophosphamide (Cytoxan)

General information

Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.
Route: IV, PO
Extravasation: no information, n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

• Acute lymphocytic leukemia
• Bone cancer
• Breast cancer
• Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)
• Hodgkin lymphoma
• Multiple myeloma
• Non-Hodgkin lymphoma
• Thymoma
• Transplant conditioning regimens

Patient drug information

• Cyclophosphamide (Cytoxan) patient drug information (Chemocare)
• Cyclophosphamide (Cytoxan) patient drug information (UpToDate)

Also known as

Alkyloxan, Biodoxan, Carloxan, Ciclofosfamida, Ciclofosfamida Filaxis, Ciclofosfamida Martian, Ciclokebir, Cyclam, Cycloblastin, Cycloblastine, Cyclo Cell, Cycloferon, Cyclomide, Cyclophar, Cyclophospham, Cyclophosphamid, cyclophosphamide monohydrate, Cyclophosphamid Farmos, Cyclophosphan, Cyclophosphan Lens, Cyclostin, Cycloxan, Cycram, Cydoxan, Cyklofosfamid, Cytophosphan, Cytoxan, Cytoxan Lyophilized, Endoxan, Endoxan-N, Endoxana, Endoxan Asta, Formitex, Genoxal, Genuxal, Hidrofosmin, Ledoxan, Ledoxina, Lyophilized Cytoxan, Neosar, Oncomide, Oncophos, Procytox, Revimmune, Sendoxan, Syklofosfamid, Trav Cyclophosphamide, Tymtran, Zycram