Difference between revisions of "Carmustine (BCNU)"
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==Patient drug information== | ==Patient drug information== | ||
*[https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d6cbb63c-e0b1-43ee-ad6f-408da0772079 Carmustine (BiCNU) package insert]<ref name="insert"></ref> | *[https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d6cbb63c-e0b1-43ee-ad6f-408da0772079 Carmustine (BiCNU) package insert]<ref name="insert"></ref> | ||
− | *[ | + | *[https://chemocare.com/chemotherapy/drug-info/carmustine.aspx Carmustine (BiCNU) patient drug information (Chemocare)]<ref>[https://chemocare.com/chemotherapy/drug-info/carmustine.aspx Carmustine (BiCNU) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/carmustine-patient-drug-information Carmustine (BiCNU) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/carmustine-patient-drug-information Carmustine (BiCNU) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/carmustine-patient-drug-information Carmustine (BiCNU) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/carmustine-patient-drug-information Carmustine (BiCNU) patient drug information (UpToDate)]</ref> | ||
Revision as of 22:06, 16 December 2021
General information
Class/mechanism: Nitrosourea, alkylates DNA and RNA, inhibits several key enzymatic processes by carbamoylation of amino acids in proteins.[1][2]
Route: IV
Extravasation: vesicant/irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Anaplastic glioma
- CNS lymphoma
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Glioblastoma
- HIV-associated lymphoma
- Hodgkin lymphoma
- Mantle cell lymphoma
- Melanoma
Diseases for which is was used
Patient drug information
- Carmustine (BiCNU) package insert[1]
- Carmustine (BiCNU) patient drug information (Chemocare)[3]
- Carmustine (BiCNU) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 3/7/1977: Initial FDA approval
- 8/17/2007: (earliest label available at Drugs@FDA) indicated as palliative therapy as a single agent or in established combination therapy with other approved chemotherapeutic agents in brain tumors—glioblastoma, brainstem glioma, medulloblastoma, astrocytoma, ependymoma, and metastatic brain tumors.
- 8/17/2007: (earliest label available at Drugs@FDA) indicated as palliative therapy for multiple myeloma in combination with prednisone
- 8/17/2007: (earliest label available at Drugs@FDA) indicated as palliative therapy for Hodgkin’s Disease as secondary therapy in combination with other approved drugs in patients who relapse while being treated with primary therapy, or who fail to respond to primary therapy.
- 8/17/2007: (earliest label available at Drugs@FDA) indicated as palliative therapy for Non-Hodgkin’s lymphomas as secondary therapy in combination with other approved drugs for patients who relapse while being treated with primary therapy, or who fail to respond to primary therapy.
Also known as
- Generic names: BCNU, bischloroethylnitrosourea, carmustin
- Brand names: Becenun, BiCNU, Carmubris, Leucerom, Nitrourean, Nitrumon
References
Categories:
- Drugs
- Intravenous medications
- Irritant
- Vesicant
- Nitrosoureas
- Alkylating agents
- Anaplastic glioma medications
- CNS lymphoma medications
- Diffuse large B-cell lymphoma medications
- Follicular lymphoma medications
- Glioblastoma medications
- HIV-associated lymphoma medications
- Hodgkin lymphoma medications
- Mantle cell lymphoma medications
- Melanoma medications
- FDA approved in 1977