Difference between revisions of "Paroxysmal nocturnal hemoglobinuria"
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| − | '''Eculizumab''' | + | <big>'''Eculizumab'''</big> |
'''Regimen:''' | '''Regimen:''' | ||
| + | |||
IV 600 mg weekly for 4 doses, followed by 900 mg 1 week later; then 900 mg every 2 weeks as maintenance treatment | IV 600 mg weekly for 4 doses, followed by 900 mg 1 week later; then 900 mg every 2 weeks as maintenance treatment | ||
'''Supportive medications''': | '''Supportive medications''': | ||
| + | |||
Meningococcal vaccine at least 2 weeks prior to treatment initiation; may revaccinate per current guidelines | Meningococcal vaccine at least 2 weeks prior to treatment initiation; may revaccinate per current guidelines | ||
'''Reference:''' | '''Reference:''' | ||
| + | |||
1)Hillmen P, Young NS, Schubert J, et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med 2006;355:1233-1243 | 1)Hillmen P, Young NS, Schubert J, et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med 2006;355:1233-1243 | ||
Revision as of 02:54, 21 October 2013
Eculizumab
Regimen:
IV 600 mg weekly for 4 doses, followed by 900 mg 1 week later; then 900 mg every 2 weeks as maintenance treatment
Supportive medications:
Meningococcal vaccine at least 2 weeks prior to treatment initiation; may revaccinate per current guidelines
Reference:
1)Hillmen P, Young NS, Schubert J, et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med 2006;355:1233-1243
2)Schubert, J., Hillmen, P., Röth, A., Young, N. S., Elebute, M. O., Szer, J., Gianfaldoni, G., Socié, G., Browne, P., Geller, R., Rother, R. P. and Muus, P. (2008), Eculizumab, a terminal complement inhibitor, improves anaemia in patients with paroxysmal nocturnal haemoglobinuria. British Journal of Haematology, 142: 263–272
3)Hill A, Kelly RJ, Kulasekararaj AG, et al. Eculizumab in paroxysmal nocturnal hemoglobinuria (PNH): a report of all 153 patients treated in the UK. Blood. Vol. 120.(21) 2012. p. 3472