Difference between revisions of "Periampullary adenocarcinoma"

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''Are you looking for a regimen, but can't find it here? For placebo or observational studies in this condition, please visit [[Periampullary adenocarcinoma - null regimens|this page]]. If you still can't find it, please let us know so we can add it!'' <br>
 
<big>Note: there is some overlap, especially in the earlier literature, between treatment regimens for periampullary adenocarcinoma and those for '''[[pancreatic cancer|pancreatic adenocarcinoma]]''', '''[[cholangiocarcinoma]]''', and '''[[gallbladder cancer]]'''; please see those pages for additional regimens.</big>
 
<big>Note: there is some overlap, especially in the earlier literature, between treatment regimens for periampullary adenocarcinoma and those for '''[[pancreatic cancer|pancreatic adenocarcinoma]]''', '''[[cholangiocarcinoma]]''', and '''[[gallbladder cancer]]'''; please see those pages for additional regimens.</big>
 
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*[https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1511 NCCN Guidelines - Ampullary Adenocarcinoma]
 
*[https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1511 NCCN Guidelines - Ampullary Adenocarcinoma]
 
**'''2023:''' Chiorean et al. [https://doi.org/10.6004/Jnccn.2023.0034 Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.] [https://pubmed.ncbi.nlm.nih.gov/37433437/ PubMed]
 
**'''2023:''' Chiorean et al. [https://doi.org/10.6004/Jnccn.2023.0034 Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.] [https://pubmed.ncbi.nlm.nih.gov/37433437/ PubMed]
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=Adjuvant therapy=
 
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==Observation==
 
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<div class="toccolours" style="background-color:#eeeeee">
 
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===Regimen===
 
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{| class="wikitable sortable" style="width: 100%; text-align:center;"
 
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!style="width: 20%"|Study
 
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!style="width: 20%"|Dates of enrollment
 
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!style="width: 20%"|[[Levels_of_Evidence#Evidence|Evidence]]
 
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!style="width: 20%"|Comparator
 
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!style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]]
 
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|-
 
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|[https://doi.org/10.1002/cncr.10831 Takada et al. 2002]
 
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|1986-1992
 
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|style="background-color:#1a9851"|Phase 3 (C)
 
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|[[#Fluorouracil_.26_Mitomycin_999|5-FU & Mitomycin]]
 
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|style="background-color:#ffffbf"|Did not meet primary endpoint of OS
 
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|-
 
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|[http://jamanetwork.com/journals/jama/fullarticle/1216477 Neoptolemos et al. 2012 (ESPAC-3)]
 
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|2000-2008
 
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|style="background-color:#1a9851"|Phase 3 (C)
 
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|1. [[#FULV_999|FULV]]<br>2. [[#Gemcitabine_monotherapy_999|Gemcitabine]]
 
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|style="background-color:#ffffbf"|Did not meet primary endpoint of OS
 
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|-
 
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''No adjuvant therapy.''
 
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<div class="toccolours" style="background-color:#cbd5e8">
 
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====Preceding treatment====
 
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*[[Surgery#Hepatobiliary_cancer_surgery|Surgery]]
 
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</div></div>
 
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===References===
 
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# Takada T, Amano H, Yasuda H, Nimura Y, Matsushiro T, Kato H, Nagakawa T, Nakayama T; Study Group of Surgical Adjuvant Therapy for Carcinomas of the Pancreas and Biliary Tract. Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phase III multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma. Cancer. 2002 Oct 15;95(8):1685-95. [https://doi.org/10.1002/cncr.10831 link to original article] [https://pubmed.ncbi.nlm.nih.gov/12365016/ PubMed]
 
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# '''ESPAC-3:''' Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Oláh A, Rawcliffe CL, Verbeke CS, Campbell F, Büchler MW; European Study Group for Pancreatic Cancer. Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. JAMA. 2012 Jul 11;308(2):147-56. Erratum in: JAMA. 2012 Nov 14;308(18):1861. [http://jamanetwork.com/journals/jama/fullarticle/1216477 link to original article] [https://pubmed.ncbi.nlm.nih.gov/22782416/ PubMed] [https://clinicaltrials.gov/study/NCT00058201 NCT00058201]
 
  
 
[[Category:Periampullary adenocarcinoma regimens]]
 
[[Category:Periampullary adenocarcinoma regimens]]
 
[[Category:Disease-specific pages]]
 
[[Category:Disease-specific pages]]
 
[[Category:Biliary tract cancers]]
 
[[Category:Biliary tract cancers]]

Latest revision as of 23:24, 15 May 2024

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Section editor
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 Eric I. Marks, MD
Boston University
Boston, MA, USA
0 regimens on this page
0 variants on this page

Are you looking for a regimen, but can't find it here? For placebo or observational studies in this condition, please visit this page. If you still can't find it, please let us know so we can add it!
Note: there is some overlap, especially in the earlier literature, between treatment regimens for periampullary adenocarcinoma and those for pancreatic adenocarcinoma, cholangiocarcinoma, and gallbladder cancer; please see those pages for additional regimens.


Guidelines

Given the rapid change in evidence in many areas of hematology/oncology, readers are encouraged to consider any guideline published 5+ years ago to be for historical purposes, only.

ESMO

NCCN

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